1 Introduction

This report includes all the R code in the analysis of ToxCast Phase 1_v2 chemical library screening results from the NIS radioactive iodide uptake (RAIU) assay. With the aim of reproducible data analysis, this document was written in Rmarkdown format and generated by the knitr and bookdown packages.

The results from this report have been published on the journal Enviornmental Science & Technology.

Citation link:

Wang J., et al., 2018. High-Throughput Screening and Quantitative Chemical Ranking for Sodium Iodide Symporter (NIS) Inhibitors in ToxCast Phase I Chemical Library. Environmental Science & Technology. DOI: 10.1021/acs.est.7b06145

Key R functions written in this analysis were compiled as an R package toxplot, and version 0.1.0 is available on CRAN. To get the most up-to-date source code please go to github. At the end of this document the source code of these functions used in this analysis is also provided.